Vipes Molecular Hydrogen Research Database

1. Type 2 Diabetes, Waterstofrijk Water

Kajiyama, S., Hasegawa, G., Asano, M., Hosoda, H., Fukui, M., Nakamura, N.,  Kitawaki, J., Imai, S., Nakano, K., Ohta, M., Adachi, T., Obayashi, H., & Yoshikawa, T. (2008). Supplementation of hydrogen-rich water improves lipid and glucose metabolism in patients with type 2 diabetes or impaired glucose tolerance. Nutrition Research, 28(3): 137–43.

2. Metabool Syndroom, Waterstofrijk Water (studie 1)

Nakao, A., Toyoda, Y., Sharma, P., Evans, M., & Guthrie, N. (2010). Effectiveness of hydrogen-rich water on antioxidant status of subjects with potential metabolic syndrome—An open label pilot study. Journal of Clinical Biochemistry and Nutrition, 46(2): 140–149. 

3. Metabool Syndroom, Waterstofrijk Water (studie 2)

Song, G., Li, M., Sang, H., Zhang, L., Li, X., Yao, S., Yu, Y., Zong, C., Xue, Y., & Qin, S. (2013). Hydrogen-rich water decreases serum LDL-cholesterol levels and improves HDL function in patients with potential metabolic syndrome. Journal of Lipid Research, 54(7): 1884–93

4. Hoog Cholesterol, Waterstofrijk Water

Song, G., Lin, Q., Zhao, H., Liu, M., Ye, F., Sun, Y., Yu, Y., Guo, S., Jiao, P., Wu, Y., Ding, G., Xiao, Q., & Qin, S. (2015). Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients with Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial. The Journal of Clinical Endocrinology & Metabolism, 100(7): 2724–33.

5. Mitochondriale en Inflammatoire Myopathieën, Waterstofrijk Water

Song, G., Lin, Q., Zhao, H., Liu, M., Ye, F., Sun, Y., Yu, Y., Guo, S., Jiao, P., Wu, Y., Ding, G., Xiao, Q., & Qin, S. (2015). Hydrogen Activates ATP-Binding Cassette Transporter A1-Dependent Efflux Ex Vivo and Improves High-Density Lipoprotein Function in Patients with Hypercholesterolemia: A Double-Blinded, Randomized, and Placebo-Controlled Trial. The Journal of Clinical Endocrinology & Metabolism, 100(7): 2724–33.

6. Lichaamssamenstelling en Metabolisme, Orale H₂ Tabletten

Korovljev, D., Trivic, T., Drid, P., & Ostojic, S. M. (2018). Molecular hydrogen affects body composition, metabolic profiles, and mitochondrial function in middle-aged overweight women.
Irish Journal of Medical Science, 87
(1): 85–89.

7. Niet-Alcoholische Leververvetting (NAFLD), Waterstofrijk Water

Korovljev, D. & Ostojic, S. M. (2019). Hydrogen-rich water reduces liver fat accumulation and improves liver enzyme profiles in patients with non-alcoholic fatty liver disease: A randomized controlled pilot trial.
Clinics and Research in Hepatology and Gastroenterology, 4
(6): 688–693.

8. NAFLD, Insulinegevoeligheid via HOMA2, Waterstofrijk Water

Korovljev, D., Javorac, D., Stajer, V., & Ostojic, S. M. (2019). Hydrogen-rich water positively affects homa2 variables in physically inactive population. Abstracts from the 5th International Scientific Conference on Exercise and Quality of Life, 3.
BMC Sports Science, Medicine and Rehabilitation, 11
(1): 7.

9. Vasculaire Endotheelfunctie, Hoge Acute Dosis Waterstofrijk Water

Sakai, T., Sato B., Hara , K., Hara, Y., Naritomi, Y., Koyanagi, S., Hara, H., Nagao, T., & Ishibashi, T. (2014). Consumption of water containing over 3.5 mg of dissolved hydrogen could improve vascular endothelial function. Vascular Health and Risk Management, 10, 591–597.

10. Cardiometabole Risicofactoren bij Ouderen, Waterstofinhalatie

Korovljev, D., Stajer, V., Javorac, D., & Ostojic, S. M. (2018). Hydrogen inhalation positively affects cardiometabolic risk factors in men and women aged 65 years or older: A preliminary report. European Geriatric Medicine, 9, 729–730.

11. Vermindering van IL-1b mRNA bij Type 2 Diabetes via Interne H₂-productie

Tamasawa, A. & Osonoi, T. (2015). Hydrogen gas production is associated with reduced interleukin-1β mrna in peripheral blood after a single dose of acarbose in Japanese type 2 diabetic patients. European Journal of Pharmacology, 762, 96–101. 

12. Lichaamssamenstelling, Lipidenprofiel en Ontstekingsmarkers bij Metabool Syndroom, Waterstofrijk Water

LeBaron, T. W., Singh, R.B., Fatima, G., Kartikey, K., Sharma, J. P., Ostojic, S. M., Gvozdjakova, A., Kura, B., Noda, M., Mojto, V., Niaz, M. A., & Slezak, J. (2020). The effects of 24-week, high-concentration hydrogen-rich water on body composition, blood lipid profiles and inflammation biomarkers in men and women with metabolic syndrome: a randomized controlled trial.
Diabetes Metabolic Syndrome and Obesity, 13, 889–896.

13. Perifere Endotheelfunctie, Waterstofrijk Water

Ishibashi, T., Kawamoto, K., Matsuno, K., Ishihara, G., Baba, T., & Komori, N. (2020). Peripheral endothelial function can be improved by daily consumption of water containing over 7 ppm of dissolved hydrogen: A randomized controlled trial. PLoS One,15(5): e0233484.

14. Perifeer Arterieel Vaatlijden, Waterstofrijk Water

Gu, Q., Liu, B., Xue, J., Zhao, M., Zhang, X., Wang, M., Zhang, M., Xue, Y., Qin, S. (2020). Effects of drinking hydrogen-rich water in men at risk of peripheral arterial disease: A randomized placebo-controlled trial. ResearchGate.

15. Antioxidatieve Activiteit, Diabetes en DNA-schade, Waterstofrijk Water

Asada, R., Tazawa, K., Sato, S., & Miwa, N. (2020). Effects of hydrogen-rich water prepared by alternating-current-electrolysis on antioxidant activity, DNA oxidative injuries, and diabetes-related markers. Medical Gas Research, 10(3), 114–121.

16. Niet-Alcoholische Leververvetting, H₂/O₂ Inhalatie (RCT)

Geru Tao, Guangjie Zhang, Wei Chen,Chao Yang,Yazhuo Xue, Guohua Song, Shucun Qin (2022) A randomized, placebo-controlled clinical trial of hydrogen/oxygen inhalation for non-alcoholic fatty liver disease.

17. Biologische Effecten van Waterstofrijk Water bij NAFLD

Kura B, Szantova M, LeBaron TW, Mojto V, Barancik M, Szeiffova Bacova B, Kalocayova B, Sykora M, Okruhlicova L, Tribulova N, Gvozdjakova A, Sumbalova Z, Kucharska J, Faktorova X, Jakabovicova M, Durkovicová Z, Macutek J, Koscová M, Slezak J. Biological Effects of Hydrogen Water on Subjects with NAFLD: A Randomized, Placebo-Controlled Trial. Antioxidants. 2022; 11(10):1935

18. Lage Dosis H₂/O₂-inhalatie bij Middelbare Leeftijd en Hypertensie

Liu B, Jiang X, Xie Y, Jia X, Zhang J, Xue Y and Qin S (2022) The effect of a low dose hydrogen-oxygen mixture inhalation in midlife/older adults with hypertension: A randomized, placebo-controlled trial. Front. Pharmacol. 13:1025487. doi: 10.3389/fphar.2022.1025487

19. Effectiviteit en Veiligheid van H₂-inhalatie bij Type 2 Diabetes

Lin Guihua, Ni Tongsu. Efficacy and safety of hydrogen inhalation therapy in patients with type 2 diabetes mellitus with poor response to metformin [J]. Advances in Clinical Medicine, 2022, 12(10): 9605-9612.

20. H₂-inhalatie als Aanvullende Therapie bij Type 2 Diabetes (Chinese Patiënten)

Zhao Z, Ji H, Zhao Y, Liu Z, Sun R, Li Y and Ni T (2023) Effectiveness and safety of hydrogen inhalation as an adjunct treatment in Chinese type 2 diabetes patients: A retrospective, observational, double-arm, real-life clinical study. Front. Endocrinol. 13:1114221. doi: 10.3389/fendo.2022.1114221

21. Verbetering van Metabole Stoornis via Darmmicrobioom, Waterstofrijk Water

Liang B, Shi L, Du D, Li H, Yi N, Xi Y, Cui J, Li P, Kang H, Noda M, et al. Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study. Antioxidants. 2023; 12(6):1245.

22. Waterstofrijk Water verbetert Darmmicrobioom bij Verstoring Glucosehuishouding

Liang B, Shi L, Du D, Li H, Yi N, Xi Y, Cui J, Li P, Kang H, Noda M, et al. Hydrogen-Rich Water Ameliorates Metabolic Disorder via Modifying Gut Microbiota in Impaired Fasting Glucose Patients: A Randomized Controlled Study. Antioxidants. 2023; 12(6):1245. https://doi.org/10.3390/antiox12061245

23. H₂-suppletie beïnvloedt CoQ10-niveaus en Mitochondriale Bio-energetica bij NAFLD

Sumbalová Z, Kucharská J, Rausová Z, Gvozdjáková A, Szántová M, Kura B, Mojto V, Slezák J. The Effect of Adjuvant Therapy with Molecular Hydrogen on Endogenous Coenzyme Q10 Levels and Platelet Mitochondrial Bioenergetics in Patients with Non-Alcoholic Fatty Liver Disease. International Journal of Molecular Sciences. 2023; 24(15):12477. https://doi.org/10.3390/ijms241512477

24. 12 Weken H₂-water: Effecten op Lichaamssamenstelling, SCFA’s en Hersenstofwisseling

Darinka Korovljev, Dejan Javorac, Nikola Todorovic, Marijana Ranisavljev, Dagrun Engeset, Tonje Holte Stea, Jelena Ostojic, Katarina Bijelic, Branislava Srdjenovic Conic, Nebojsa Kladar, Laszlo Ratgeber, Nenad Trunic, Sava Rajkovic, Valdemar Stajer and Sergej M. Ostojic The Effects of 12-Week Hydrogen-Rich Water Intake on Body Composition, Short-Chain Fatty Acids Turnover, and Brain Metabolism in Overweight Adults: A Randomized Controlled Trial

25. Weinig Effect van Ionizer-geproduceerd H₂-water bij Metabool Syndroom

Moribe R, Minami M, Hirota R, J-P NA, Kabayama S, Eitoku M, Yamasaki K, Kuroiwa H, Suganuma N. Health Effects of Electrolyzed Hydrogen Water for the Metabolic Syndrome and Pre-Metabolic Syndrome: A 3-Month Randomized Controlled Trial and Subsequent Analyses. Antioxidants. 2024; 13(2):145.

26. H₂ + PQQ Supplementatie beïnvloedt Mitochondriën en Cognitie bij Lichte Cognitieve Stoornis

Sonja Baltic, David Nedeljkovic, Nikola Todorovic, Marijana Ranisavljev, Darinka Korovljev, Jelena Cvejic, Jelena Ostojic, Tyler W. LeBaron, Judi Timmcke, Valdemar Stajer, Sergej M. Ostojic, The impact of six-week dihydrogen-pyrroloquinoline quinone supplementation on mitochondrial biomarkers, brain metabolism, and cognition in elderly individuals with mild cognitive impairment: a randomized controlled trial, The Journal of nutrition, health and aging, Volume 28, Issue 8, 2024, 100287, ISSN 1279-7707

27. Veiligheid en Lipidenverlagende Potentie van H₂-rijk Koraalcalcium bij Metabool Syndroom

Chiu S-H, Douglas FL, Chung J-R, Wang K-Y, Chu C-F, Chou H-Y, Huang W-C, Wang T-Y, Chen W-W, Shen M-C, Liu F-C and Hsiao P-J (2023) Evaluation of the safety and potential lipid-lowering effects of oral hydrogen-rich coral calcium (HRCC) capsules in patients with metabolic syndrome: a prospective case series study. Front. Nutr. 10:1198524. doi: 10.3389/fnut.2023.1198524

28. H₂-inhalatie beïnvloedt Ruststofwisseling bij Gezonde Vrouwen

Grepl, Pavel1; Botek, Michal1; Krejčí, Jakub1,*; McKune, Andrew2,3. Molecular hydrogen inhalation modulates resting metabolism in healthy females: findings from a randomized, double-blind, placebo-controlled crossover study. Medical Gas Research ():10.4103/mgr.MEDGASRES-D-24-00085, February 08, 2025. | DOI: 10.4103/mgr.MEDGASRES-D-24-00085

Sportprestaties, Herstel en Gezondheid van Atleten

In deze sectie worden 44 humane studies weergegeven die waterstoftherapie onderzoeken in relatie tot sportprestaties, fysiek herstel, blessureherstel en de algemene gezondheid van atleten. De meeste onderzoeken maakten gebruik van waterstofrijk water als toedieningsvorm: 26 studies onderzochten de orale inname van waterstofwater (waarvan er één geen positief effect vond), 4 studies gebruikten topisch waterstofwater of -gel, 4 studies onderzochten inhalatie van waterstofgas, 1 studie gebruikte waterstoftabletten die intern waterstof genereren, 1 studie keek naar het effect van H₂-rijke calciumpoeder, 1 studie testte een waterstof-verrijkte sportdrank. Een van deze studies combineerde orale tabletten met een topische gel, waardoor het totaal op 44 unieke onderzoek interventies komt.

1. Hydrogenwater verbetert uithoudingsvermogen en vermindert vermoeidheid

Mikami, T., Tano, K., Lee, H., Lee, H., Park, J., Ohta, F., LeBaron, T. W., & Ohta, S. (2019). Drinking hydrogen water enhances endurance and relieves psychometric fatigue: a randomized, double-blind, placebo-controlled study. Canadian Journal of Physiology and Pharmacology, 97(9): 857–862. 

2. Invloed van H₂-water op darmflora bij jonge vrouwelijke sporters
Sha, J.-B., Zhang, S.-S., Lu, Y.-M., Gong, W.-J., Jiang, X.-P., Wang, J.-J., Qiao, T.-L., Zhang, H.-H., Zhao, M.-Q., Wang, D.-P., Xia, H., Li, Z.-W., Chen, J.-L., Zhang, L., & Zhang, C.-G. (2018). Effects of the long-term consumption of hydrogen-rich water on the antioxidant activity and the gut flora in female juvenile soccer players from Suzhou, China. Medical Gas Research, 8(4): 135–143. 

3. Lagere hartslag bij inspanning dankzij een dosis H₂-water

LeBaron, T. W., Larson, A. J., Ohta, S., Mikami, T., Barlow, J. Bullock, J., & DeBeliso, M. (2019). Acute supplementation with molecular hydrogen benefits submaximal exercise indices. randomized, double-blinded, placebo-controlled crossover pilot study. Journal of Lifestyle Medicine, 9(1): 36–43. 

4. H₂-water verhoogt VO₂max en inspanningscapaciteit bij vrouwen met overgewicht
Ostojic, S., Korovljev, D., Stajer, V., & Javorac, D. (2018). 28-days hydrogen-rich water supplementation affects exercise capacity in mid-age overweight women. Medicine & Science in Sports & Exercise, 50(5S): 728–729. 

5. Bescherming tegen oxidatieve schade na intensief sporten met H₂-water

Sun, Y.-P. & Sun, L. 2017. Selective protective effect of hydrogen water on free radical injury of athletes after high-intensity exercise. Biomedical Research, 28(10).  

6. Drie dagen intensieve training: H₂-water beïnvloedt redoxbalans positief

Shibayama, Y.; Takeuchi, K., Dobashi, S., & Koyama, K. (2017). Hydrogen-rich water modulates redox status repeated three consecutive days of strenuous exercise. Medicine & Science inMedicine & Science inSports & Exercise, 49(5S): 941.

7. H₂-water vermindert spiervermoeidheid bij topatleten
Aokia, K., Nakao, A., Adachi, T., Matsui, Y., & Miyakawa, S. (2012). Pilot study: Effects of drinking hydrogen-rich water on muscle fatigue caused by acute exercise in elite athletes. Medical Gas Research, 2, 12.

8. Langdurige intervaltraining en H₂-water: betere prestaties?
Da Ponte, A., Giovanelli, N., Nigris, D., & Lazzer, S. (2017). Effects of hydrogen rich water on prolonged intermittent exercise. The Journal of Sports Medicine and Physical Fitness, 58(5): 612–621. 

9. Minder verzuring na training met H₂ als aanvulling?
Drid, P., Trivic, T., Casals, C., Trivic, S., Stojanovic, M., & Ostojic, S. M. (2016). Is molecular hydrogen beneficial to enhance post-exercise recovery in female athletes? Science & Sports. 

10. Herstel van weke delen bij sportblessures met H₂ inname en gel
Ostojic, S. M., Vukomanovic, B., Calleja-Gonzalez, J., & Hoffman, J. R. (2015). Effectiveness of oral and topical hydrogen for sports-related soft tissue injuries. Postgraduate Medicine, 126(5).

11. Ventilatie en lactaatrespons verbeteren met H₂-water
Botek, M., Krejci, J., McKune, A., & Sládečková, B. (2019). Hydrogen rich water improved ventilatory, perceptual and lactate responses to exercise. International Journal of Sports Medicine.

12. Hydrogenbaden verminderen spierpijn na zware training
Kawamura, T., Gando, Y., Takahashi, M., Hara, R., Suzuki, K., & Muraoka, I.  (2016). Effects of hydrogen bathing on exercise-induced oxidative stress and delayed-onset muscle soreness. Western Pacific Region Index Medicus. 

13. Koyama, et al. (2008). Vermindering van oxidatieve stress in urine na H₂-rijke elektrolytoplossing Anti-Aging Med.

14. Sneller herstel na training bij judoka’s door waterstofwater
Drid, P., Stojanovic, M. D.M., Trivic, T., & Ostojic, S. M. (2016). Molecular hydrogen affected post-exercise recovery in judo athletes. Medicine & Science in Sports & Exercise, 48(5S): 1071

15. Verbeterde antioxidantencapaciteit bij vrouwelijke topsporters
Minghao, et al. (2017). Effects of hydrogen-rich water on antioxidant capacity in female judo athletes in training. Chin J Sports Med.*
*IN CHINESE, ENGLISH ABSTRACT AVAILABLE

16. Minder melkzuuropbouw bij intensieve inspanning dankzij H₂-water 
Li Chen. (2015). Hydrogen rich-water on blood lactic acid after repeated exhaustive exercise. Journal of Taishan Medical College. * IN CHINESE, ENGLISH ABSTRACT AVAILABLE

17. Enkelscheur bij atleet behandeld met lokale H₂-hydrotherapie
Dejan, J. & Stajer, V. Case report: acute hydrotherapy with super-saturated hydrogen-rich water for ankle sprain in a professional athlete [version 1; peer review: awaiting peer review].

18. Verbeterde sportprestaties bij gezonde volwassenen na H₂-inhalatie
Javorac, D., Stajer, V., Ratgeber, L., Betlehem, J., & Ostojic, S. M. (2019). Short-term H₂ inhalation improves exercise performance in healthy adults. Biology of Sport, 36(4): 333–339. 

19. Geen merkbaar effect van éénmalige H₂-inname op duurloopprestaties
Ooi, C. H., Ng, S. K., & Omar, E. A. (2019). Acute ingestion of hydrogen-rich water does not improve incremental treadmill running performance in endurance-trained athletes. Applied Physiology and Research Metabolism, 45(5)

20. H₂-water verhoogt uithoudingsvermogen bij sporters en proefdieren
Wu, P. (2020). Hydrogen-rich water improves the physical ability of football players and the anti-fatigue ability of rats, Revista Cientifica, 30(1): 428-435.

21. Lichte verbetering sportprestaties met H₂ in warme omstandigheden
Ito, H., Kabayma, S., & Goto, K. (2020).Ito, H., Kabayma, S., & Goto, K. (2020).Effects of electrolyzed hydrogen water ingestion during endurance exercise in a heated environment on body fluid balance and exercise performance. Temperature, 7(3): 290–299.

22. H₂-therapie even effectief als RICE-behandeling bij enkelblessures
Javorac, D., Stajer, V., Ratgeber, L., Olah, A., Betlehem, J., Acs, P., Vukomanovic, B., & Ostojic, S. M. (2020). Hydrotherapy with hydrogen-rich water compared with RICE protocol following acute ankle sprain in professional athletes: a randomized non-inferiority pilot trial. Research in Sports Medicine, 1–9.

23. Inhalatie van H₂/O₂-mix ondersteunt herstel na zware inspanning
Shibayama, Y., Dobashi, S., Fukuoka, T., Arisawa, T., Koyama, K. (2020). The effects of rich hydrogen and oxygen mixed gas inhalation after high intensity exercise influence on exercise performance. Medicine & Science in Sports & Exercise, 52(7S): 1024–1025.

24. H₂-bad vermindert spierschade en spierpijn na excentrisch trainen
Todorovic, N. Javorac, D., Stajer, V., & Ostojic, S. M. (2020). The effects of supersaturated hydrogen-rich water bathing on biomarkers of muscular damage and soreness perception in young men subjected to high-intensity eccentric exercise. Journal of Sports Medicine.

25. Onzeker effect van H₂ bij bergopwaartse hardloopprestaties
Botek, M., Krejčí, J., McKune, A. J., & Sládečková, B. Hydrogen-rich water supplementation and up-hill running performance: Effect of athlete performance level. International Journal of Sports Physiology and Performance, 15(8): 1193–1196

26. H₂ vermindert melkzuur en LDH na krachttraining bij sporters
Moradi, B., Saberi, E., Hasani, & A., Saheb, A. M. The role of drinking hydrogen-rich water produced by alkaline stick on resistance exercise in athletes.

27. H₂-inhalatie beperkt spierafbraak en oxidatieve stress na training
Shibayama, Y., Dobashi, S., Arisawa, T., Fukuoka, T., & Koyama, K. (2020). Impact of hydrogen-rich gas mixture inhalation through nasal cannula during post-exercise recovery period on subsequent oxidative stress, muscle damage, and exercise performances in men. Medical Gas Research, 10(4): 155–162.

28. Capsules met H₂ ondersteunen ademhaling en sportoutput
Alharbi, A. A. D., Ebine, N., Nakae, S., Hojo, T., & Fukuoka, Y. (2020). Application of molecular hydrogen as an antioxidant in responses to ventilatory and ergogenic adjustments during incremental exercise in humans. Nutrients, 13(2): 459

29. Sneller herstel van teenblessure met H₂-verzadigd waterbad
Alex Tarnava, A. (2021). Supersaturated hydrogen-rich water hydrotherapy for recovery of acute injury to the proximal phalanges on the 5th toe: a case report. Journal of Science and Medicine, 3(1)

30. Zevendaagse H₂-inname verbetert prestaties bij sporters en niet-sporters
Timón, R., Olcina, G., González-Custodio, A., Camacho-Cardenosa, M., Camacho-Cardenosa, A., & Martínez Guardado, I. (2021). Effects of 7-day intake of hydrogen-rich water on physical performance of trained and untrained subjects. Biology of Sport 38(2): 269–275

31. H₂ helpt antioxidantcapaciteit behouden bij zware inspanningen
Dobashi, S., Takeuchi, K., & Koyama, K. (2020). Hydrogen-rich water suppresses the reduction in blood total antioxidant capacity induced by 3 consecutive days of severe exercise in physically active males. Medical Gas Research, 10(1): 21–26

32. H₂-inname verhoogt piekzuurstofopname bij fietsproef
Hori, A., Sobue, S., Kurokawa, R., Hirano, S.-I., Ichihara, M., & Hotta, N. Two-week continuous supplementation of hydrogenrich water increases peak oxygen uptake during an incremental cycling exercise test in healthy humans: a randomized, single-blinded, placebo-controlled study.  Medical Gas Research, 10(4): 163–169.

33. Betere spieroutput en minder spierpijn na H₂-consumptie
Botek, M., Krejci, J., Mckune, A. J., Valenta, M., & Sládečková, B. (2021). Hydrogen rich water consumption positively affects muscle performance, lactate response, and alleviates delayed onset of muscle soreness after resistance training. Journal of Strength and Conditioning Research,

34. H₂-verrijkte calcium ondersteunt sportieve ademhaling
Alharbi, A. A. D., Ebine, N., Nakae, S., Hojo, T., & Fukuoka, Y. (2021). Application of Molecular Hydrogen as an Antioxidant in Responses to Ventilatory and Ergogenic Adjustments during Incremental Exercise in Humans. Nutrients, 13(2): 459.

35. Versnelde vetverbranding tijdens training door H₂-inhalatie

Hori, A., Kimura, H., Kondo, T., Ichihara, M., Ogata, H., Hotto, N. (2020). Inhalation of molecular hydrogen increases breath acetone excretion during submaximal exercise: a randomized, single-blinded, placebo-controlled study. Medical Gas Research, (10)3

36. Functionele H₂-drank verbetert fysieke en mentale prestaties

LeBaron T., Kharman J., McCullough M. (2021). Effects of an H2-infused, Nitric Oxide-Producing Functional Beverage on Exercise and Cognitive Performance. Journal of Science and Medicine; 3(2):1-15

37. H₂-inhalatie vermindert vermoeidheid en activeert hersenfunctie

Hong Y, Dong G, Li Q, Wang V, Liu M, Jiang G, Bao D and Zhou J (2022) Effects of pre-exercise H2 inhalation on physical fatigue and related prefrontal cortex activation during and after high-intensity exercise. Front. Physiol. 13:988028.

38. H₂ bevordert spierkracht en vermindert vertraagde spierpijn

Botek, Michal1; Krejčí, Jakub1; McKune, Andrew2,3; Valenta, Michal1; Sládečková, Barbora1. Hydrogen Rich Water Consumption Positively Affects Muscle Performance, Lactate Response, and Alleviates Delayed Onset of Muscle Soreness After Resistance Training. Journal of Strength and Conditioning Research: October 2022 – Volume 36 – Issue 10 – p 2792-2799
doi: 10.1519/JSC.0000000000003979

39. Korte H₂-inname verhoogt kracht en versnelt hartslagherstel

Dong G, Fu J, Bao D, Zhou J. Short-Term Consumption of Hydrogen-Rich Water Enhances Power Performance and Heart Rate Recovery in Dragon Boat Athletes: Evidence from a Pilot Study. International Journal of Environmental Research and Public Health. 2022; 19(9):5413.

40. Darmbacteriën die H₂ aanmaken helpen bij spierherstel

Eda, N.; Tsuno, S.; Nakamura, N.; Sone, R.; Akama, T.; Matsumoto, M. Effects of Intestinal Bacterial Hydrogen Gas Production on Muscle Recovery following Intense Exercise in Adult Men: A Pilot Study. Nutrients 2022, 14, 4875.

41. Koudwatertherapie met H₂/CO₂-mix verbetert spierherstel

Miho Yoshimura , Masatoshi Nakamura , Kazuki Kasahara , Riku Yoshida  ,Yuta Murakami , Tatsuya Hojo , Goichi Inoue, Naohisa Makihira,Yoshiyuki Fukuoka Effect of CO2 and H2 gas mixture in cold water immersion on recovery after eccentric loading

42. H₂-inname vermindert spierpijn na duurloop bij ongetrainde mannen

Valenta, M., Botek, M., Krejčí, J., Chmelík, F., Sládečková, B., Klimešová, I., & Šinclová, M. (2023). SUPPLEMENTATION WITH HYDROGENATED WATER REDUCES THE MANIFESTATIONS OF POST-EXERCISE MUSCLE PAIN AFTER ENDURANCE RUNNING IN UNTRAINED MEN. A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED CROSS OVER STUDY. Journal REHABILITÁCIA, 60(4), 290–301. https://doi.org/10.61983/lcrh.v60i4.17

43. Sneller spierherstel bij topzwemmers na twee zware trainingen met H₂

Sládečková B, Botek M, Krejčí J, Valenta M,McKune A, Neuls F and Klimešová I (2024), Hydrogen-rich water supplementation
promotes muscle recovery after two strenuous training sessions performed on the same day in elite fin swimmers: randomized, double-blind, placebo-controlled, crossover trial. Front. Physiol. 15:1321160. doi: 10.3389/fphys.2024.1321160

44. Acht dagen H₂-inname verhoogt spieruithoudingsvermogen en herstel

Zhou K, Yuan C, Shang Z, Jiao W and Wang Y (2024) Effects of 8 days intake of hydrogen-rich water on muscular endurance performance and fatigue recovery during resistance training. Front. Physiol. 15:1458882. doi: 10.3389/fphys.2024.1458882

Hersenherstel, Neurologische Aandoeningen en Breingezondheid

In deze sectie worden 21 humane studies weergegeven die de effecten van waterstoftherapie onderzoeken op het gebied van hersenherstel na acute schade, neurologische aandoeningen en algemene hersengezondheid.
In tegenstelling tot andere categorieën zijn de gebruikte toedieningsmethoden hier meer verspreid: 7 studies gebruikten waterstofrijk water (waarvan er één geen positief effect vond), 6 studies onderzochten inhalatie van waterstofgas (waarvan er twee geen positief effect vonden), 2 studies gebruikten waterstofrijke zoutoplossing (saline), 1 studie onderzocht intraveneuze toediening van waterstof, 1 studie testte een functionele drank verrijkt met waterstof en stikstofoxide. Deze onderzoeken richten zich op verschillende neurologische uitkomsten, zoals cognitief herstel, hersenmetabolisme en de vermindering van oxidatieve stress in het centrale zenuwstelsel.

1. Mild Cognitive Impairment, Hydrogen Water

Nishimaki, K., Asada, T., Ohsawa, I., Nakajima, E., Ikejima, C., Yokota, T., Kamimura, N., & Ohta, S. (2018). Effects of molecular hydrogen assessed by an animal model and a randomized clinical study on mild cognitive impairment. Current Alzheimer Research., 15(5): 482–492.

2. Improving Outcomes of Alzheimer’s, Hydrogen Inhalation

Ono, H., Nishijima, Y., Sakamoto, M., Horikosi, T., Tamaki, M., Oishi, W., Naitoh, Y., Futaki, T., Ishii, S., Suzuki, K., Kurihara H., & Ohta, S. (2018). Pilot Study on Therapeutic Inhalation of Hydrogen Gas for Improving Patients with Alzheimer’s Disease Assessed by Cognitive Subscale Scores and Magnetic Resonance Diffusion Tensor Imaging. International Journal of Alzheimers & Neurological Disorders, 1(1): 004.

3. Acute Cerebral Infarction, Hydrogen Inhalation

Ono, H., Nishijima, Y., Ohta, S., Sakamoto, M., Kinone, K., Horikosi, T., Tamaki, M., Takeshita, H., Futatuki, T., Ohishi, W., Ishiguro, T., Okamoto, S., Ihsii, S., & Takanami, H. (2017). Hydrogen gas inhalation treatment in acute cerebral infarction: A randomized controlled clinical study on safety and neuroprotection. Journal of Stroke & Cerebrovascular Diseases, 26(11): 2587–2594.

4. Acute Cerebral Ischemia, Hydrogen Inhalation

Ono, H., Nishijima, Y., Adachi, N., Sakamoto, M., Kudo, Y., Kaneko, K., Nakao, A., & Imaoka, T. (2012). A basic study on molecular hydrogen (H₂) inhalation in acute cerebral ischemia patients for safety check with physiological parameters and measurement of blood H₂ level. Medical Gas Research, 9(21).

5. Acute Brain Stem Infarct, Hydrogen Saline + Edaravone

Ono, H., Nishijima, Y., Adachi, N., Tachibana, S., Chitoku, S., Mukaihara, S., Sakamoto, M., Kudo, Y., Nakazawa, J., Kanedo, K., & Nawashiro, H. (2011). Improved brain MRI indices in the acute brain stem infarct sites treated with hydroxyl radical scavengers, Edaravone and hydrogen, as compared to Edaravone alone. a non-controlled study. Medical Gas Research, 1(12).

6. Acute Cerebral Infarction, Hydrogen Saline + Edaravone

Nagatani, K., Nawashiro, H., Takeuchi, S., Tomura, S., Otani, N., Osada, H., Wada, K., Katch, H., Tsuzuki, N., & Mori, K. (2013). Safety of intravenous administration of hydrogen-enriched fluid in patients with acute cerebral ischemia: initial clinical studies. Medical Gas Research, 3: 13. 

7. Newborn Abnormal Neurological Function, Hydrogen Water

Yang, L, Li, D., & Chen, S. (2016). Hydrogen water reduces NSE, IL-6, and TNF-α levels in hypoxic-ischemic encephalopathy. Open Medicine, 11(1): 399–406.

8. Parkinson’s, Hydrogen Water

Yoritaka, A., Takanashi, M., Hirayama, M., Nakahara, T., Ohta, S., & Hattori, N.  (2013). Pilot study of H₂ therapy in parkinson’s disease: a randomized double-blind placebo-controlled trial. Movement Disorders, 28(6): 836–9.

9. Parkinson’s Disease, No Result, Hydrogen Water****

Yoritaka et al., (2018). Randomized, double-blind, multicenter trial of hydrogen water for Parkinson’s disease. Movement Disorders.

****Bij een van de klinische studies naar het effect van waterstoftherapie op Parkinson ging het mis in de uitvoering: er waren grote fouten in de placebo-controlegroep, waarbij deelnemers per ongeluk ook hoge doses waterstof kregen toegediend. Zowel de behandelgroep als de placebogroep lieten opmerkelijke verbeteringen zien – niet ten opzichte van elkaar, maar wel ten opzichte van verwachtingen en vergelijkbare onderzoeken. Het vermoeden is dat beide groepen regelmatig waterstof binnenkregen: De ene groep dagelijks, de andere mogelijk om de dag, vermeld wordt dat ook de placebogroep een concentratie van minstens 0,16 mg/L ontving. De exacte doseringsroutine is niet bekend. Hierdoor is er geen betrouwbare vergelijking tussen beide groepen mogelijk.

Belangrijk: Op dit moment kan er niet worden geconcludeerd dat moleculaire waterstof (H₂) effectief is bij Parkinson. Het bewijs is onvoldoende en tegenstrijdig. Het is ethisch onverantwoord om H₂-producten specifiek te promoten of aan te prijzen voor patiënten met Parkinson. Zolang wetenschappelijk bewijs ontbreekt, moet terughoudendheid en eerlijkheid de norm zijn.

10. Parkinson’s Disease, No Result, Hydrogen Inhalation

Hirayama, M., Ito, M., Minato, T., Yoritaka, A., LeBaron, T. W., & Ohno, K. (2018). Inhalation of hydrogen gas elevates urinary 8-hydroxy-2′-deoxyguanine in Parkinson’s disease. Medical Gas Research, 8(4): 144–149.

11. Concussion Recovery Case Study, Hydrogen Water

Javorac, D., Stajer, V., & Ostojic, S. M. (2019). Case Report: Buccal Administration of Hydrogen-Producing Blend After a Mild Traumatic Brain Injury in a Professional Athlete. [version 1; peer review: 2].F1000 Research, 8: 1024.

12. Cognitive Function in Elderly, Hydrogen Inhalation

Korovljev, D., Trivic, T., Stajer, V., Drid, P., Sato, B., & Ostojic, S. M. (2019). Short-term H₂ inhalation improves cognitive function in older women: A pilot study. International Journal of Gerontology, 14 (2): 149–150.

13. Hydrogen Water vs. Caffeine for Improving Alertness After Sleep Deprivation, Hydrogen Water

Zanini, D., Stajer, V., & Ostojic, S. M. (2020). Hydrogen vs. caffeine for improved alertness in sleep-deprived humans. Neurophysiology 52, 67–72.

14. Photobiomodulation on Parkinson Disease, Hydrogen Water

Hong, C.-T., Hu, C. J., Lin, H.-Y., & Wu, D. (2021). Effects of concomitant use of hydrogen water and photobiomodulation on Parkinson disease: A pilot study. Medicine (Baltimore), 100(4): e24191.

15. Subarachnoid Hemorrhage, Intravenous Hydrogen Therapy

Takeuchi, S., Kumagai, K., Toyooka, T., Otani, N., Wada, K., & Mori, K. (2021). Intravenous Hydrogen Therapy With Intracisternal Magnesium Sulfate Infusion in Severe Aneurysmal Subarachnoid Hemorrhage. Stroke, 52(1), 20–27. 

16. Parkinson’s Disease, No Result, Hydrogen Inhalation

Yoritaka, A., Kobayashi, Y., Hayashi, T., Saiki S., Hattori, N. (2021). Randomized double-blind placebo-controlled trial of hydrogen inhalation for Parkinson’s disease: a pilot study. Neurological Sciences

17. Neuroprotective Agent for TBIs and Concussions, An H2-Infused, Nitric Oxide-Producing Beverage

LeBaron, W. T., Kharman, J., McCullough, L. Michael. (2021). An H2-infused, nitric oxide-producing functional beverage as a neuroprotective agent for TBIs and concussions. Journal of Integrative Neuroscience, 20(3).

18. Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia

Tomoyoshi Tamura, Masaru Suzuki, Koichiro Homma, Motoaki Sano, Ryoji Iizuka, Hiromichi Narimiya, Ryosuke Tsuruta, Kotaro Kaneda, Motoki Fujita, Junichi Sasaki, Osamu Akasaka, Keisuke Sawai, Makiko Nozaki, Hiroshi Imai, Ken Ishikura, Kaoru Ikejiri, Yasuyuki Kakihana, Shuhei Niiyama, Takahiro Futatsuki, Masahiro Honda, Yasuhiro Ikeda, Hideo Oka, Hideaki Yoshihara, Hirokazu Onishi, Susumu Yamashita, Koki Shimizu, Toshihiro Sakurai, Shu Yamada, Hiroshi Fukami, Nobuaki Shime, Kei Suzuki, Yasuhiro Kuroda, Kenya Kawakita, Akio Kimura, Tatsuki Uemura, Kiyotsugu Takuma, Kunio Kanao, Youichi Yanagawa, Ikuto Takeuchi, Efficacy of inhaled hydrogen on neurological outcome following brain ischaemia during post-cardiac arrest care (HYBRID II): a multi-centre, randomised, double-blind, placebo-controlled trial, eClinicalMedicine, Volume 58, 2023,101907, ISSN 2589-5370.

19. Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial

Rahman MH, Bajgai J, Sharma S, Jeong E-S, Goh SH, Jang Y-G, Kim C-S, Lee K-J. Effects of Hydrogen Gas Inhalation on Community-Dwelling Adults of Various Ages: A Single-Arm, Open-Label, Prospective Clinical Trial. Antioxidants. 2023; 12(6):1241.

20. Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans

Korovljev D, Ostojic J, Todorovic N, Ostojic SM. Molecular hydrogen modulates brain glutamate/GABA-glutamine cycle in overweight humans. Arch Med Sci. 2023 Jul 13;19(4):1151-1153. doi: 10.5114/aoms/162938. PMID: 37560746; PMCID: PMC10408004.

21. Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas

Hirano, Shin-ichi*; Ichikawa, Yusuke; Sato, Bunpei; Takefuji, Yoshiyasu; Satoh, Fumitake. Successful treatment of myalgic encephalomyelitis/chronic fatigue syndrome using hydrogen gas: four case reports. Medical Gas Research 14(2):p 84-86, June 2024. | DOI: 10.4103/2045-9912.385441

Huidgezondheid en Waterstoftherapie

Hier worden 16 humane studies weergegeven die het effect van waterstoftherapie op de huid onderzoeken, waaronder toepassingen bij huidveroudering, ontstekingen, wondgenezing en hydratatie. De toedieningsvormen in deze studies zijn gevarieerd: 5 studies gebruikten topisch waterstofwater (direct op de huid aangebracht), 3 studies onderzochten orale inname van waterstofrijk water, 2 studies gebruikten waterstofrijke zoutoplossing (saline), 1 studie maakte gebruik van inhalatie van waterstofgas. In totaal zijn er 13 unieke toedieningsvormen binnen 11 publicaties, omdat een studie meerdere methodes tegelijk onderzocht: inhalatie, orale inname en saline-toediening. Deze studies wijzen op mogelijke voordelen van moleculaire waterstof voor de huid.

1. Psoriasis, Hydrogen Water Baths

Zhu, Q., Wu, Y., Li, Y, Chen. Z., Wang, L., Xiong, H., Dai, E., Wu, J., Fan, B., Ping, L., Luo, X. (2018).  Positive effects of hydrogen-water bathing in patients of psoriasis and parapsoriasis en plaques. Sci Rep 8, 8051.

2. Wrinkles Reduction, Hydrogen Water Baths

Kato, S., Saitoh, Y., Iwai, K., & Miwa, N. (2012). Hydrogen-rich electrolyzed warm water represses wrinkle formation against uva ray together with type-i collagen production and oxidative-stress diminishment in fibroblasts and cell-injury prevention in keratinocytes. Journal of Photochemistry and Photobiology, 106, 24–33.

3. Red Skin/Inflamed Diseases, Hydrogen Saline

Ono, H., Nishijima, Y., Adachi, N., Sakamoto, M., Kudo, Y., Nakazawa, J., Kaneko, K., & Nakao, A. (2012). Hydrogen(H₂) treatment for acute erythymatous skin diseases. A report of 4 patients with safety data and a non-controlled feasibility study with H₂ concentration measurement on two volunteers. Medical Gas Research, 2(1): 14.

4. Psoriasis, Skin Lesions, Case Studies, Hydrogen Water+Saline+Gas

Ishibashi, T., Ichikawa, M., Sato, B., Shibata, S., Hara, Y., Naritomi, Y., Okazaki, K., Nakashima, Y., Iwamoto, Y., Koyanagi, S., Hara, H., & Nagao, T. (2015). Improvement of psoriasis-associated arthritis and skin lesions by treatment with molecular hydrogen: A report of three cases. Molecular Medicine Reports, 12(2): 2757–64.

5. Pressure Ulcers, Hydrogen Water

Li, Q., Kato, S., Matsuoka, D., Tanaka, H., & Miwa, N. (2013). Hydrogen water intake via tube-feeding for patients with pressure ulcer and its reconstructive effects on normal human skin cells in vitro. Medical Gas Research, 3(1): 20.

6. Graft vs. Host Disease Case Study, Hydrogen Water (Drinking)

Qian, L.-R., & Shen, J.-L. (2016). Successful treatment with hydrogen rich water in a case of chronic graft-versus-host-disease. Medical Gas Research, 6(3): 177–179.

7. UV Damage in Skin in Vivo, Topical Hydrogen Water

Shin, M. H., Park, R., Nojima, H., Kim, H.-C., Kim, Y. K., & Chung, J. H. (2013). Atomic hydrogen surrounded by water molecules, H(H₂O)m, modulates basal and UV-induced gene expressions in human skin in vivo. PLOS One, 8(4): e61696.

8. Keratin Plugged Hair Pores, Hydrogen Water Baths

Tanaka, Y., Saitoh, Y., & Miwa, N. (2018). Electrolytically generated hydrogen warm water cleanses the keratin-plug-clogged hair-pores and promotes the capillary blood-streams, more markedly than normal warm water does. Medical Gas Research, 8(1): 12–18.

9. Visceral Fat and Skin Blotches, Hydrogen Water Baths

Asada, R., Saitoh, Y., & Miwa, N. (2019). Effects of hydrogen-rich water bath on visceral fat and skin blotch, with boiling-resistant hydrogen bubbles. Medical Gas Research, 9(2): 68–73.

10. Skin Aging and Antioxidant Activity, Hydrogen Water Mask

Kwon, H.-J., Han, S.-B., & Park, K.-W. (2020). Antioxidant activity of hydrogen water mask pack composed of gel-type emulsion and hydrogen generation powder. International Journal of Molecular Sciences, 21(24): 9731.

11. Heat Retention Effects, Hydrogen Baths

Kato, S., Takada, Y., & Miwa, N. (2021). Heat-retention effects of hydrogen-rich water bath assessed by thermography for humans. Journal of Thermal Biology, 95: 102805.

12. Acne Vulgaris in Adult Women, Topical Hydrogen Purification

Chilicka, K., Rogowska, A., & Szyguła, R. (2021). Effects of topical hydrogen purification on skin parameters and acne vulgaris in adult women. Healthcare, 9(2): 144.

13. Hydrogen-Rich Water Improve Wrinkles and Blotches

Yoshiharu T. Nobuhiko M.  (2022) Repetitive Bathing and Skin Poultice with Hydrogen-Rich Water Improve Wrinkles and Blotches Together with Modulation of Skin Oiliness and Moisture, 3(2):161-178.

14. Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity

Tanaka Y, Xiao L, Miwa N. Hydrogen-rich bath with nano-sized bubbles improves antioxidant capacity based on oxygen radical absorbing and inflammation levels in human serum. Med Gas Res 2022;12:91-9

15. Repetitive Bathing and Skin Poultice with Hydrogen-Rich Water Improve Wrinkles and Blotches

Tanaka Y, Miwa N. Repetitive Bathing and Skin Poultice with Hydrogen-Rich Water Improve Wrinkles and Blotches Together with Modulation of Skin Oiliness and Moisture. Hydrogen. 2022; 3(2):161-178.

16. The effects of hydrogen-oxygen mixed gas on skin blood flow in healthy adults

YU Yang, ZHAO Yun-Lai, SONG Guo-Hua, QIN Shu-Cun. The effects of hydrogen-oxygen mixed gas on skin blood flow in healthy adults[J]. Editorial Office of Chinese Journal of Arteriosclerosis,2018,26(6):557-560.

Reumatoïde Artritis

Hier worden 2 klinische studies weergegeven die het effect van waterstoftherapie bij reumatoïde artritis (RA) onderzoeken. Hoewel de eerste resultaten veelbelovend zijn, is het aantal studies op dit gebied nog beperkt. In een studie werden positieve resultaten behaald met hooggedoseerd waterstofrijk water, in de andere studie werd een gunstig effect waargenomen bij gebruik van waterstofrijke zoutoplossing (saline). 

1. Vermindering van symptomen bij reumatoïde artritis met waterstofzoutoplossing

Ishibashi, T., Sato, B., Shibata, S., Sakai, T., Hara, Y., Naritomi, Y., Koyanagi, S., Hara, H., & Nagao, T. (2014). Therapeutic efficacy of infused molecular hydrogen in saline on rheumatoid arthritis: a randomized, double-blind, placebo-controlled pilot study. International Immunopharmacology, 21(2): 468–73.

2. Positieve effecten van waterstofrijk water bij reumatoïde artritis

Ishibashi, T., Sato, B., Rikitake, M., Seo, T., Kurokawa, R., Hara, Y., Naritomi, Y., Hara, H., & Nagao, T. (2012). Consumption of water containing a high concentration of molecular hydrogen reduces oxidative stress and disease activity in patients with rheumatoid arthritis: An open-label pilot study. Medical Gas Research, 2(1): 27.

Dialyse

Hier worden 6 humane studies weergegeven waarin waterstoftherapie is toegepast bij patiënten die dialyse ondergaan. Alle zes deze studies maakten gebruik van waterstofrijke zoutoplossing (saline) als toedieningsvorm van het waterstofgas. De onderzoeken richten zich onder andere op het verminderen van oxidatieve stress, ontsteking en cardiovasculaire complicaties die vaak voorkomen bij dialysepatiënten. 

1. Waterstofoplossing bij peritoneale dialyse vermindert oxidatieve stress

Terawaki, H., Hayashi, Y., Zhu, W.-J., Matsuyama, Y., Terada, T., Kabayama, S., Watanabe, T., Era, S., Sato, B., & Nakayama, M. (2013). Transperitoneal administration of dissolved hydrogen for peritoneal dialysis patients: a novel approach to suppress oxidative stress in the peritoneal cavity. Medical Gas Research, 3, Article 14.

2. Waterstofrijke zoutoplossing in hemodialyse vermindert ontstekingsreacties

Nakayama, M., Nakano, H., Hamada, H., Itami, N., Nakazawa, R., & Ito, S. (2010). A novel bioactive haemodialysis system using dissolved dihydrogen (H₂) produced by water electrolysis: A clinical trial. Nephrology Dialysis Transplantation, 25(9): 3026–3033.

3. Biologische effecten van lage concentraties waterstof in dialysewater

Nakayama, M., Kabayama, S., Nakano, H., Zhu, W.-J., Terawaki, H., Nakayama, K., Katoh, K., Satoh, T., & Ito, S. (2009). Biological effects of electrolyzed water in hemodialysis. Nephron Clinical Practice, 112(1): c9–15.

4. Verbeterde prognose bij chronische dialysepatiënten met waterstofdialyse

Nakayama, M., Itami, N., Suzuki, H., Hamada, H., Yamamoto, R., Tsunoda, K., Osaka, N., Nakano, H., Maruyama, Y., Kabayama, S., Nakazawa, R., Miyazaki, M., & Ito, S. (2018). Novel haemodialysis (HD) treatment employing molecular hydrogen (H₂)-enriched dialysis solution improves prognosis of chronic dialysis patients: A prospective observational study. Scientific Reports, 8, Article 254.

5. Toename van beschermende eiwitvormen tijdens waterstofdialyse

Maeda, K., Yoshizaki, S., Iida, T., Terada, T., Era, S., Sakashita, K., & Arikawa, H. (2016). Improvement of the fraction of human mercaptalbumin on hemodialysis treatment using hydrogen-dissolved hemodialysis fluid: A prospective observational study. Renal Replacement Therapy, 2, Article 42.

6. 12-maandsobservatie toont klinische verbeteringen bij 262 dialysepatiënten

Nakayama, M., Itami, N., Suzuki, H., Hamada, H., Osaka, N., Yamamoto, R., Tsunoda, K., Nakano, H., Watanabe, K., Zhu, W.-J., Maruyama, Y., Terawaki, H., Kabayama, S., Nakazawa, R., Miyazaki, M., & Ito, S. (2017). Possible clinical effects of molecular hydrogen (H₂) delivery during hemodialysis in chronic dialysis patients: Interim analysis in a 12 month observation. PLOS One, 12(9): e0184535.

Vermindering van Bijwerkingen bij Chemo- en Radiotherapie

Hier worden 2 klinische studies weergegeven waarin wordt onderzocht of waterstoftherapie kan helpen bij het verminderen van bijwerkingen van chemotherapie en radiotherapie. Beide onderzoeken maakten gebruik van waterstofrijk water als toedieningsvorm.

1. Vermindering van bijwerkingen bij radiotherapiepatiënten met waterstofrijk water

Kang, K.-M., Kang, Y.-N., Choi, I.-B., Gu, Y., Kawamura, T., Toyoda, Y., & Nakao, A.  (2011). Effects of drinking hydrogen-rich water on the quality of life of patients treated with radiotherapy for liver tumors. Medical Gas Research, 1(1): 11.

2. Bescherming van leverfunctie bij chemotherapie door waterstofwater

Yang, Q., Ji, G., Pan, R., Zhao, Y., & Yan, P. (2017). Protective effect of hydrogen-rich water on liver function of colorectal cancer patients treated with mFOLFOX6 chemotherapy. Molecular and Clinical Oncology, 7(5): 891–896.

Waterstoftherapie bij Kanker

Hier worden 6 gepubliceerde studies weergegeven die het gebruik van waterstoftherapie onderzoeken bij kankerpatiënten gericht op de kanker zelf. Alle onderzoeken maakten gebruik van inhalatie van waterstofgas als toedieningsmethode.

1. Colorectale kanker: waterstofinhalatie herstelt uitgeputte CD8+ T-cellen

Akagi, J., & Baba, H. (2019). Hydrogen gas restores exhausted CD8+ T cells in patients with advanced colorectal cancer to improve prognosis. Oncology Reports, 41(1): 301–311.

2. Stadium III–IV kanker: cohortstudie bij 82 patiënten met waterstofinhalatie

Chen, J.-B., Kong, X.-F., Lv, Y.-Y., Qin, S.-C., Sun, X.-J., Mu, F., Lu, T.-Y., & Xu, K.-C. (2019). “Real world survey” of hydrogen-controlled cancer: A follow-up report of 82 advanced cancer patients. Medical Gas Research, 9(3): 115–121.

3. Galblaaskanker: casus met tumorregressie na waterstofinhalatie

Chen, J.-B., Mu, F., Lu, T., Ma, Y., Du, D., & Xu, K. (2019). A gallbladder carcinoma patient with pseudo-progressive remission after hydrogen inhalation. OncoTargets and Therapy, 12, 8645–8651.

Chen, J.-B., Pan, Z.-B., Du, D.-M., Qian, W., Ma, Y.-Y., Mu, F., & Xu, K.-C. (2019). Hydrogen gas therapy induced shrinkage of metastatic gallbladder cancer: A case report. World Journal of Clinical Cases, 7(15): 2065–2074.

4. Beenmergschade bij kankerbehandeling: bescherming door waterstofinhalatie

Hirano, S.-I., Aoki, Y., Kurokawa, R., Li, X.-K., Ichimaru, N., Takahara, S., & Takefuji, Y. Protective effect of hydrogen gas inhalation on radiation-induced bone marrow damage in cancer patients: a retrospective observational study.

5. Longkanker: betere werking van immunotherapie door waterstofinhalatie

Akagi, J., & Baba, H. (2020). Hydrogen gas activates coenzyme Q10 to restore exhausted CD8+ T cells, especially PD-1+Tim3+terminal CD8+ T cells, leading to better nivolumab outcomes in patients with lung cancer. Spandidos Publications, Article 258.

6. Niet-kleincellige longkanker: immuun verjonging door 2 weken H₂-inhalatie

Chen, J.-B., Kong, X.-F., Qian, W., Mu, F., Lu, T.-Y., Lu, Y.-Y., & Xu, K.-C. (2020). Two weeks of hydrogen inhalation can significantly reverse adaptive and innate immune system senescence patients with advanced non-small cell lung cancer: A self-controlled study. Medical Gas Research, 10(4), 149–154.

Antioxidantwerking van Waterstoftherapie

Hier worden 4 humane studies weergegeven die specifiek gericht zijn op de antioxidant-achtige werking van waterstoftherapie bij mensen. Alle vier de studies gebruikten waterstofrijk water als toedieningsvorm.

1. Verhoogde antioxidantenzymen in bloed bij gezonde mannen door H₂-water

Trivic, T., Vojnovic, M., Drid, P., & Ostojic, S. M. (2017). Drinking hydrogen-rich water for 4 weeks positively affects serum antioxidant enzymes in healthy men: A pilot study. Current Topics in Nutraceutical Research, 15(1).

2. Bloedverzuring wordt verminderd door waterstofrijk water

Trivic, T., Vojnovic, M., Drid, P., & Ostojic, S. M. (2017). Drinking hydrogen-rich water for 4 weeks positively affects serum antioxidant enzymes in healthy men: A pilot study. Current Topics in Nutraceutical Research, 15(1).

3. Minder ontstekingsreacties en celdood bij gezonde volwassenen

Sim, M., Kim, C.-S., Shon, W.-J., Lee, Y.-K., Choi, E. Y., & Shin, D.-M. (2020). Hydrogen-rich water reduces inflammatory responses an prevents apoptosis of peripheral blood cells in healthy adults: A randomized, double-blind, controlled trial. Scientific Reports, 10(1): 12130.

4. Toename antioxidantcapaciteit en verlaging van oxidatieve stressmarkers

Hiraoka, A., Sasaki, S., Yamada, T., Shinohara, A., & Chiba, M. (2006). Effects of drinking a water product with anti-oxidant activities in vitro on the blood levels of biomarker substances for the oxidative stress. Journal of Health Science, 52(6): 817–820.

Overige Toepassingen van Waterstof

Hier worden 39 humane studies weergegeven die niet onder de eerder genoemde categorieën vallen, maar waarin waterstoftherapie wordt onderzocht voor algemene of uiteenlopende gezondheidsvoordelen.
Van deze 39 studies: 15 studies gebruikten waterstofrijk water als toedieningsvorm, in één daarvan werd geen statistisch significant effect gevonden, maar er werd wel een mogelijke subgroep van responders geïdentificeerd, 9 studies maakten gebruik van waterstofinhalatie
De overige studies gebruikten verschillende of gecombineerde toedieningsvormen. Deze onderzoeken richten zich bijvoorbeeld op slaapkwaliteit, stemming, glucosehuishouding, spijsvertering, algemene energiebalans en andere fysiologische processen.

1. Hepatitis B, Waterstofrijk water

Xia, C., Liu, W., Zeng, D., Zhu, L., Sun, X., & Sun, X. (2013). Effect of hydrogen-rich water on oxidative stress, liver function, and viral load in patients with chronic hepatitis B. Clinical and Translational Science, 6(5): 372–5.

2. Post-cardiac arrest, Inhalatie van waterstofgas

Tamura, T., Hayashida, K., Sano, M., Suzuki, M., Shibusawa, T., Yoshizawa, J., Kobayashi, Y., Suzuki, T., Ohta, S., Morisaki, H., Fukuda, K., & Hori, S. (2016). Feasibility and safety of hydrogen gas inhalation for post-cardiac arrest syndrome – First-in-human pilot study. Circulation Journal, 80(8): 1870–1873.

3. Hartoperatie, Inhalatie van waterstofgas

Katsumata, Y., Sano, F., Abe, T., Tamura, T., Fujisawa, T., Shiraishi, Y., Kohsaka, S., Ueda, I., Homma, K., Suzuki, M., Okuda, S., Maekawa, Y., Kobayashi, E., Hori, S., Sasaki, J., Fukuda, K., & Sano, M. (2017). The effects of hydrogen gas inhalation on adverse left ventricular remodeling after percutaneous coronary intervention for ST-elevated myocardial infarction — first pilot study in humans. Circulation Journal, 81(7): 940–947.

4. Verbetering van stemming, angst en autonome zenuwfunctie door waterstofrijk water

Mizuno, K., Sasaki, A. T., Ebisu, K., Tajima, K., Kajimoto, O., Nojima, J., Kuratsune, H., Hori, H., & Watanabe, Y. (2017). Hydrogen-rich water for improvements of mood, anxiety, and autonomic nerve function in daily life. Medical Gas Research, 7(4): 247–255.

5. Waterstofrijk water als aanvulling op behandeling van parodontitis

Azuma, T., Yamane, M., Ekuni, D., Kawabata, Y., Kataoka, K., Kasuyama, K., Maruyama, T., Tomofuji, T., & Morita, M. (2015). Drinking hydrogen-rich water has additive effects on non-surgical periodontal treatment of improving periodontitis: A pilot study. Antioxidants, 4(3): 513–522.

6. Verhoging van bloedalkalisatie door waterstofrijk water (studie 1)

Ostojic, S. M. (2012). Serum alkalinization and hydrogen-rich water in healthy men. Mayo Clinic Proceedings, 87(5): 501–502.

7. Verhoging van bloedalkalisatie door waterstofrijk water (studie 2)

Ostojic, S. M., & Stojanovic, M. D. (2012). Hydrogen-rich water affected blood alkalinity in physically active men. Research in Sports Medicine, 22(1): 49–60.

8. Geen effect op pijnlijke blaassyndroom, mogelijk kleine respondergroep

Matsumoto, S., Ueda, T., & Kakizaki, H. (2013). Effect of supplementation with hydrogen-rich water in patients with interstitial cystitis/painful bladder syndrome. Urology, 81(2): 226–230.

9. Invloed van waterstofrijk water op ontlasting en slaapfunctie

Tanaka, Y., Saihara, Y., Izumotani, K., & Nakamura, H. (2018). Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, including gastrointestinal symptoms. Medical Gas Research, 8(4): 160–166.

10. Vermindering van ademhalingsinspanning bij tracheale stenose door H₂-inhalatie

Zhou, Z.-Q., Zhong, C.-H., Su, Z.-Q., Li, X.-Y., Chen, Y., Chen, X.-B., Tang, C.-L., Zhou, L.-Q., & Li, S.-Y. (2019). Breathing hydrogen-oxygen mixture decreases inspiratory effort in patients with tracheal stenosis. Respiration, 97(1): 42–51.

11. Vermindering van oxidatieve stress bij refluxziekte door waterstofrijk water

Franceschelli, S., Gatta, D. M. P., Pesce, M., Ferrone, A., Di Martino, G., Di Nicola, M., De Lutiis, M. A., Vitacolonna, E., Patruno, A., Grilli, A., Felaco, M., & Speranza, L. (2018). Modulation of the oxidative plasmatic state in gastroesophageal reflux disease with the addition of rich water molecular hydrogen: A new biological vision. Journal of Cellular and Molecular Medicine, 22(5): 2750–2759.

12. Waterstofrijk water vermindert ontsteking en apoptose bij gezonde volwassenen

Sim, M., Kim, C.-S., Shon, W.-J., Lee, Y.-K., Choi, E. Y., & Shin, D.-M. (2020). Hydrogen-rich water reduces inflammatory responses and prevents apoptosis of peripheral blood cells in healthy adults: A randomized, double-blind, controlled trial. Scientific Reports 10, Article 12130.

13. Hydrogeen-inhalatie verbetert benauwdheid en ernst bij COVID-19-patiënten

Guan, W.-J., Wei, C.-H., Chen, A.-L., Sun, X.-C., Guo, G.-Y., Zou, X., Shi, J.-D., Lai, P.-Z., Zheng, Z.-G., & Zhong, N.-S. (2020). Hydrogen/oxygen mixed gas inhalation improves disease severity and dyspnea in patients with Coronavirus disease 2019 in a recent multicenter, open-label clinical trial.

14. Therapeutisch effect van waterstof bij chronische graft-versus-hostziekte

Qian, L., Liu, M., Shen, J., Cen, J., & Zhao, D. (2020). Hydrogen in patients with corticosteroid-refractory/dependent chronic graft-versus-host-disease: a single-arm, multicenter, open-label, phase 2 trial. Frontiers in Immunology.

15. Waterstofrijke zoutoplossing voor behandeling van allergische rhinitis

Jin, L., Fan, K., Zhang, X., Zhao, Y., Ge, Q., Wang, Y., & Yu, S. (2020). [Changes of nasal nitric oxide in the treatment of allergic rhinitis with hydrogen-rich saline lavage of nasal cavity]. Lin Chung Er Bi Yan Hou Tou Jing Wai Ke Za Zhi, 34(3): 244–247.

16. Bescherming van het hoornvlies tijdens oogchirurgie met H₂-oplossing

Igarashi, T., Ohsawa, I., Kobayashi, M., Umemoto, Y., Arima, T., Suzuki, H., Igarashi, T., Otsuka, T., & Takahashi, H. (2019). Effects of hydrogen in prevention of corneal endothelial damage during phacoemulsification: A prospective randomized clinical trial. American Journal of Ophthalmology, 207, 10–17.

17. Voorkomen van droge ogen met H₂-producerende melk

Kawashima, M., Tsuno, S., Matsumoto, M., & Tsubota, K. (2019). Hydrogen-producing milk to prevent reduction in tear stability in persons using visual display terminals. The Ocular Surface,17(4): 714–721.

18. Invloed van H₂-inhalatie op immuunfunctie bij middelbare leeftijd

Chen, J.-B., Kong, X.-F., & Mu, F. (2021). High-flow hydrogen inhalation might suppresses the immune function of middle-aged participants: A self-controlled study. Medical Gas Research, 11(1), 12–17.

19. Vermindering van oxidatieve stress na hartstilstand door H₂-inhalatie

Tamura, T., Suzuki, M., Hayashida, K., Kobayashi, Y., Yoshizawa, J., Shibusawa, T., Sano, M., Hori, S., & Sasaki, J. (2020). Hydrogen gas inhalation alleviates oxidative stress in patients with post-cardiac arrest syndrome. Journal of Clinical Biochemistry and Nutrition, 67(2): 214–221.

20. Toepassing van moleculaire waterstof tijdens hartchirurgie met hart-longmachine

Danilova D.A., Brichkin Yu.D., Medvedev A.P., Pichugin V.V., Fedorov S.A., Taranov E.V., Nazarov E.I., Ryazanov M.V., Bolshukhin G.V., Deryugina A.V. (2021). Application of Molecular Hydrogen in Heart Surgery under Cardiopulmonary Bypass. Sovremennye Tehnologii v Medicine.

21. Stimulatie van sympathische hartactiviteit bij vrouwen door waterstofrijk water

Botek, M., Sládečková, B., Krejčí, J., Pluháček, F., Najmanová, E. (2021). Acute hydrogen-rich water ingestion stimulates cardiac autonomic activity in healthy females. Acta Gymnica, 51, Article e2021.009.

22. Behandeling van kwaadaardige zenuwpijn met H₂-water

Li, D. Yan, M. (2016). Clinical assessment of hydrogen-rich water and oxycodone hydrochloride controlled-release tablets in the treatment of malignant neuropathic pain. Journal of Chinese Physician, 18(9):1329-1331,1335

23. H₂-supplement verbetert traanproductie bij droge ogen

Kubota, M. Kawashima, M, Inoue, S., Imada, T., Nakamura, S., Kubota, S., Watanabe, M, Takemura, R., Tsubota, K. (2021). Randomized, crossover clinical efficacy trial in humans and mice on tear secretion promotion and lacrimal gland protection by molecular hydrogen. Scientific Reports 11, Article 6434

24. Hydrogeen-inhalatie bij acute exacerbaties van COPD

Zheng, ZG., Sun, WZ., Hu, J.Y., Jie, ZJ., Xu, JF., Cao, J., Song, YL., Wang, CH., Wang, J., Zhao, H., Guo, ZL., Zhong, NS. (2021). Hydrogen/oxygen therapy for the treatment of an acute exacerbation of chronic obstructive pulmonary disease: results of a multicenter, randomized, double-blind, parallel-group controlled trial. Respiratory Research, 22, 149

25. Effect op verouderingsbiomarkers bij ouderen na H₂-watergebruik

Zanini, D., Todorovic, N., Korovljev, D., Stajer, V., Ostojic, J., Purac, J., Kojic, D., Vukasinovic, E., Djordjievski, S., Sopic, M., Guzonjic, A., Ninic, A., Erceg, S., Ostojic, S.M. (2021). The effects of 6-month hydrogen-rich water intake on molecular and phenotypic biomarkers of aging in older adults aged 70 years and over: A randomized controlled pilot trial. Experimental Gerontology, 155

26. Consistentie van ontlasting en darmflora bij gebruik van H₂-opgelost water

Tanaka, Y., Kiuchi, M., Higashimura, Y., Naito, Y., & Koyama, K. (2021). The effects of ingestion of hydrogen-dissolved alkaline electrolyzed water on stool consistency and gut microbiota: a double-blind randomized trial. Medical Gas Research, 11,4

27. COVID-19: H₂ als aanvullende therapie bij zuurstofverzadiging en uithoudingsvermogen

Singh, RB., Halabi, G., Fatima, G., Rai, RH., Tarnava, AT., LeBaron, TW. (2021). Molecular hydrogen as an adjuvant therapy may be associated with increased oxygen saturation and improved exercise tolerance in a COVID-19 patient. Clin Case Rep., 9:e05039

28. Chronische vermoeidheid na COVID-19 verlicht door H₂-inhalatie

Shogenova, L., Truong, T., Kryukova, N. & Yusupkhodzhaeva, K. & Pozdnyakova, D. & Kim, T. & Chernyak, A. & Kalmanova, Е & Medvedev, O. & Kuropatkina, T. & Varfolomeev, S. & Ryabokon, A. & Svitich, O. & Kostinov, M. & Kunio, Ibaraki & Hiroki, Maehara & Chuchalin, A.. (2021). Hydrogen inhalation in rehabilitation program of the medical staff recovered from COVID-19. Cardiovascular Therapy and Prevention, 20(6): 2986.

29. Waterstofinname vermindert kater- en alcoholsymptomen bij gezonde volwassenen

Lv X, Lu Y, Ding G, et al. Hydrogen Intake Relieves Alcohol Consumption and Hangover Symptoms in Healthy Adults: a Randomized and Placebo-Controlled Crossover Study [published online ahead of print, 2022 Sep 16]. Am J Clin Nutr. 2022;nqac261. doi:10.1093/ajcn/nqac261

30. H₂-inhalatietherapie bij plotselinge doofheid

Okada M, Ogawa H, Takagi T, Nishihara E, Yoshida T, Hyodo J, Shinomori Y, Honda N, Fujiwara T, Teraoka M, Yamada H, Hirano S-i and Hato N (2022) A double-blinded, randomized controlled clinical trial of hydrogen inhalation therapy for idiopathic sudden sensorineural hearing loss. Front. Neurosci. 16:1024634. doi: 10.3389/fnins.2022.1024634

31. Invloed van H₂-water op spermakwaliteit bij mannen

Valdemar Stajer, Nikola Todorovic, Branislava Sr?enovi? ?oni?, Nebojsa Kladar, Dagrun Engeset, Tonje Holte Stea, Laszlo Ratgeber, Jozsef Betlehem, Pongrac Acs, Scott C. Forbes, Darren G. Candow and Se

32. H₂/zuurstoftherapie bij gewone COVID-19-patiënten

Zeng, Y., Guan, W., Wang, K. et al. Effect of hydrogen/oxygen therapy for ordinary COVID-19 patients: a propensity-score matched case-control study. BMC Infect Dis 23, 440 (2023). https://doi.org/10.1186/s12879-023-08424-4

33. H₂-alkalisch water bij chronische constipatie

Sharma S, Kim Y, Bajgai J, Rahman MH, Jeong YJ, Goh SH, Park HJ, Kim C-S, Kim HI, Lee K-J. The Effect of Electrolyzed Hydrogen-Rich Alkaline Reduced Water on Patients with Chronic Constipation—A Clinical Trial. Processes. 2023; 11(7):2142.

34. Hydrogeen en PQQ verhogen antioxidanten in spiercellen

Bloomer RJ, Zhang Y, Shirazi JY, Okegbe C, Pence J, Martin K, Q. Timmcke J, LeBaron TW. Alpha Hope, via Molecular Hydrogen and Pyrroloquinoline Quinone, Dose-Dependently Increases Nrf2 and PGC-1α Levels in C2C12 Myoblasts. Processes. 2023; 11(7):2011.

35. Betere functie van rode bloedcellen na operatie door H₂-inhalatie

Deryugina, Anna Vaycheslavovna1; Danilova, Darya Andreevna MS1,*; Brichkin, Yurii Dmitrievich2; Taranov, Evgenii Vladimirovich2; Nazarov, Evgenii Ivanovich3; Pichugin, Vladimir Viktorovich2; Medvedev, Aleksandr Pavlovich2,4; Riazanov, Michail Valerevich2; Fedorov, Sergey Andreevich2; Smorkalov, Andrej Yurevich2; Makarov, Evgenii Vladimirovich2. Molecular hydrogen exposure improves functional state of red blood cells in the early postoperative period: a randomized clinical study. Medical Gas Research 13(2):p 59-66, Apr–Jun 2023.

36. H₂-water in combinatie met psychologische therapie bij paniekstoornis

Darinka Korovljev, Nikola Todorovic, Marijana Ranisavljev, Bogdan Andjelic, Nebojsa Kladar, Valdemar Stajer, Sergej M. Ostojic, Fernández-Serrano AB, Moya-Faz FJ, Giner Alegría CA, Fernández Rodríguez JC, Soriano Guilabert JF, Del Toro Mellado M. Effects of hydrogen water and psychological treatment in a sample of women with panic disorder: a randomized and controlled clinical trial. Health Psychol Res. 2022 May 30;10(3):35468. doi: 10.52965/001c.35468. PMID: 35774917; PMCID: PMC9239392.

37. H₂-water vermindert PMS-klachten en verbetert kwaliteit van leven

Behboudi-Gandevani S, Hariri FZ, Moghaddam-Banaem L. The effect of omega 3 fatty acid supplementation on premenstrual syndrome and health-related quality of life: a randomized clinical trial. J Psychosom Obstet Gynecol. 2018;39:266–72.

38. H₂-water verlicht vermoeidheid bij long-COVID, maar niet benauwdheid

Tan, Y.; Xie, Y.; Dong, G.; Yin, M.; Shang, Z.; Zhou, K.; Bao, D.; Zhou, J. The Effect of 14-Day Consumption of Hydrogen-Rich Water Alleviates Fatigue but Does Not Ameliorate Dyspnea in Long-COVID Patients: A Pilot, Single-Blind, and Randomized, Controlled Trial. Nutrients 2024, 16, 1529. https://doi.org/10.3390/nu16101529

39. H₂-water verlaagt urinezuur bij mensen met jicht

Fenglin Wu, Jun Ma, Junli Xue, Xue Jiang, Jinyu Liu, Jiashuo Zhang, Yazhuo Xue, Boyan Liu, Shucun Qin. Effects of hydrogen-rich water on blood uric acid in patients with hyperuricemia: A randomized placebo-controlled trial https://doi.org/10.1016/j.heliyon.2024.e36401

40. Combinatie van H₂-inhalatie en hypothermie na hartstilstand

Tamura, Tomoyoshi MD^1,2; Narumiya, Hiromichi MD³; Homma, Koichiro MD^1,2; Suzuki, Masaru MD⁴;  Efficacy of Inhaled Hydrogen on Neurologic Outcome Following Brain Ischemia During PostCardiac Arrest Care (HYBRID II) Study Group

41. H₂-inhalatie vermindert reactieve zuurstof in bloed – gerandomiseerde studie

Mohamed Chair, Hashem AlAani, Sevda Lafci Fahrioglu, Cherif Ben Hamda, Umut Fahrioglu, Tamer Degheidy, The impact of hydrogen inhalation therapy on blood reactive oxygen species levels: A randomized controlled study, Free Radical Biology and Medicine, Volume 222, 2024, Pages 601-606, ISSN 0891-5849, https://doi.org/10.1016/j.freeradbiomed.2024.07.010.

42. Hydrogeen-inhalatie als aanvullende therapie bij hoge bloeddruk

Ji H, Sun H, Zhang Y, Zhao Z, Gao X, Wang C, Yang Y, Zhang X, Gao J, Man D, Yang Q, Yang Y, Yue C, Chen C, Ding X and Ni T (2024) Effectiveness and safety of hydrogen inhalation therapy as an additional treatment for hypertension in real-world practice: a retrospective, observational study in China. Front. Cardiovasc. Med. 11:1391282. doi: 10.3389/fcvm.2024.1391282

43. H₂ herstelt darmmicrobioom bij opioïdverslaving – dier- en mensstudie

Bing Xie, Yong Wang, Yun Lu, Mengmeng Wang, Rongji Hui, Hailei Yu, Wenbo Li, Ludi Zhang, Feng Yu, Zhiyu Ni, Bin Cong, Chunling Ma, Di Wen,
A novel intervention of molecular hydrogen on the unbalance of the gut microbiome in opioid addiction: Experimental and human studies, Biomedicine & Pharmacotherapy, Volume 178, 2024, 117273, ISSN 0753-3322, https://doi.org/10.1016/j.biopha.2024.117273.

Elektrisch Gereduceerd Water en Magnesiumgebaseerde Innameproducten (–ORP)

Producten zoals "ionisch water" of "geëlektrolyseerd water" worden geproduceerd via elektrolyse, waarbij moleculaire waterstof (H₂) in wisselende hoeveelheden in het water wordt opgelost. Dit proces zorgt voor een negatieve ORP-waarde (oxidatiereductiepotentieel), wat vaak wordt gepresenteerd als indicator voor antioxidatieve werking. Evenzo genereren producten op basis van elementair magnesium, die worden gepromoot voor hun negatieve ORP, deze waarde door het aanmaken van moleculaire waterstof in water. Hoewel het waarschijnlijk is dat het gezondheidsvoordeel in deze producten voortkomt uit de aanwezigheid van H₂, is in de betreffende studies de exacte hoeveelheid waterstofgas of dosering vaak niet gerapporteerd.

Daarom zijn deze onderzoeken niet opgenomen in de hoofdsectie van het moleculaire waterstofonderzoek, maar worden ze apart vermeld als gerelateerd aan –ORP-principes, met mogelijk werkingsmechanisme via H₂-productie.

1. Ionisch water bij spijsverteringsklachten

Tashiro, H., Hokudo, T., Ono, H., Fujiyama, Y., & Baba, T. (2000). Clinical evaluation of alkaline ionized water for abdominal complaints: Placebo controlled double blind tests. Digestion & Absorption.

2. Gereduceerd water bij dialysepatiënten (oxidatieve stress)

Huang, K.-C., Yang, C.-C., Lee, K.-T., & Chien, C.-T. (2003). Reduced hemodialysis-induced oxidative stress in end-stage renal disease patients by electrolyzed reduced water. Kidney International, 64(2), 704–14.

3. "Anti-oxidant water" en biomarkers voor oxidatieve stress

Hiraoka, A., Sasaki, S., Yamada, T., Shinohara, A., & Chiba, M. (2006). Effects of drinking a water product with anti-oxidant activities in vitro on the blood levels of biomarker substances for the oxidative stress. Journal of Health Science, 52(6): 817–820.

Vermeldt waterstofgas als werkzame antioxidant, maar geeft geen concentratie aan.
Stelt dat de antioxidatieve werking in vitro sterker was dan in vivo, zonder rekening te houden met het feit dat dezelfde concentraties in een lichaam niet direct overdraagbaar of representatief zijn voor klinische effecten.

4. Erytrocytenbescherming bij dialyse via gereduceerd water

Huang, K.-C., Yang, C.-C., Hsu, S.-P., Lee, K.-T., Liu, H.-W., Morisawa, S., Otsubo, K., & Chien, C.-T. (2006). Electrolyzed-reduced water reduced hemodialysis-induced erythrocyte impairment in end-stage renal disease patients. Kidney International, 70(2), 391–8.

5. Prestatiewinst met ultra-negatief geladen water

Bittner, A. C., Bittner, R. C. L., Lile, Jr., K., & Sakuragi, Y. (2007). Intra-individual ergonomics (I²E): Performance effects of ultra-negative-ion water.

6. Alkalisch water bij diabetes type 2

Yang, E. J., Kim, J. R., Ryang, Y. S., Kim, D. H., Deung, Y. K., Park, S. K., & Lee, K. J. (2007). A clinical trial of orally administered alkaline reduced water.

7. Biologische effecten van elektrolysewater bij hemodialyse

Nakayama, M., Kabayama, S., Nakano, H., Zhu, W.-Z., Terawaki, H., Nakayama, K., Katoh, K., Satoh, T., & Ito, S. (2009) Biological effects of electrolyzed water in hemodialysis. Nephron Clinical Practice, 112(1), c9–15.

8. T-celherstel bij chronische dialysepatiënten via gereduceerd water

Huang, K.-C., Hsu, S.-P., Yang, C.-C., Yang, P.-O., Lee, K.-T., Morisawa, S., Otsubo, K., & Chien, C.-T. (2010). Electrolysed-reduced water dialysate improves T-cell damage in end-stage renal disease patients with chronic haemodialysis. Nephrology Dialysis, Transplantation, 25(8) 2730–7.

9. Magnesiumrijke drank met negatieve ORP en sportprestaties

Ostojic, S. (2011). Drinks with alkaline negative oxidative reduction potential improve exercise performance in physically active men and women: Double-blind, randomized, placebo-controlled, cross-over trial of efficacy and safety. Serbian Journal of Sports Sciences, 5(3): 83–89.

10. Dagelijkse inname van water met waterstof en elektrolyse-effect

Tanaka, Y., Saihara, Y., Izumotani, K., & Nakamur, H. (2018). Daily ingestion of alkaline electrolyzed water containing hydrogen influences human health, including gastrointestinal symptoms. Medical Gas Research, 8(4), 160–166.

11. Combinatie van wandelen en alkalisch water bij diabetes

Rias, Y. A., Kurniawan, A. L., Chang, C. W., Gordon, C. J., & Tsai, H. T. (2020). Synergistic effects of regular walking and alkaline electrolyzed water on decreasing inflammation and oxidative stress, and increasing quality of life in individuals with type 2 diabetes: A community based randomized controlled trial. Antioxidants, 9(10), 946.

12. Overige Studies

Daarnaast worden hier 4 aanvullende studies vermeld waarvoor geen officiële publicatielinks beschikbaar zijn en die niet terug te vinden zijn in Engelstalige wetenschappelijke tijdschriften. 

1. Fujiyama, Y. & Kitahora, T. (2004). Alkaline electrolytic water (alkali ions water) for drinking water in medicine. Mizu no Tokusei to Atarashii Riyo Gijutsu, Enu-Ti-Esu, Tokyo, 348–457.

2. Lee, K.J., et al., (2004). Effect of electrolyzed-reduced water: In vivo and in vitro examination and clinical trials, in the 3rd Asia Pacific conference on evidence-based medicine. Hong Kong.

3. Lu, K. C., et al. (2006). Electrolyzed reduced water attenuates hemodialysis-induced mononuclear cells apoptosis in end-stage renal disease patients. Nephrology, Dialysis, Transplantation, 21, 200–201.

4. Yeung, L. K., et al. (2006). Effect of electrolyzed reduced water hemodialysis on peripheral lymphocyte intracellular cytokine expression. Nephrology, Dialysis, Transplantation, 21, 204–204.

Magnesiumimplantaten en Waterstofproductie

Onderzoekers binnen het vakgebied van biologisch afbreekbare magnesiumimplantaten weten goed dat de afbraak van magnesium gepaard gaat met de productie van moleculaire waterstof (H₂). In sommige studies wordt de vorming van waterstofgas zelfs actief gebruikt om de afbraaksnelheid van het implantaat in het lichaam te monitoren.

Toch lijken de potentiële therapeutische effecten van deze vrijgekomen waterstof grotendeels onbenut en niet erkend in dit onderzoeksveld. De studies bevatten doorgaans geen informatie over de exacte hoeveelheid H₂ die wordt gevormd, noch over de hoeveelheid magnesium of de reactiesnelheid die nodig zou zijn om effecten te kunnen extrapoleren. Hierdoor blijven deze onderzoeken buiten het directe kader van waterstoftherapie. Niettemin zijn deze studies belangrijk en zouden ze op de radar moeten blijven, omdat ze mogelijk een rol gaan spelen in de verdere onderbouwing van moleculaire waterstof als therapeutisch middel in de toekomst.

 Zhao, D., Wu, J., Chou, D.-T., Hoagland, W., Benson, D., Dong, Z., Kumta, P. N., & Heineman, W. R. (2020). Visual hydrogen mapping sensor for noninvasive monitoring of bioresorbable magnesium implants in vivo. JOM, 72, 1851–1858.

1. Langetermijn biodegradatie van Mg-legeringen

Lee, J.-W., Han, H.-S., Han, K.-J., Park, J., Jeon, H., Ok, M.-R., Seok, H.-K., Ahn, J.-P., Lee, K. E., Lee, D.-H., Yang, S.-J., Cho, S.-Y., Cha, P.-R., Kwon, H., Nam, T.-H., Han, J. H. L., Rho, H.-J., Lee, K.-S., Kim, Y.-C., & Mantovani, D. (2016). Long-term clinical study and multiscale analysis of in vivo biodegradation mechanism of Mg alloy. Proceedings of the National Academy of Sciences of the United State of America, 113(3), 716–21.

2. Magnesium schroeven bij Hallux Valgus

Plaass, C., Ettinger, S., Sonnow, L., Koenneker, S., Noll, Y., Weizbauer, A., Reifenrath, J., Claassen, L., Daniilidis, K., Stukenborg-Colsman, C., & Windhagen, H. (2016). Early results using a biodegradable magnesium screw for modified chevron osteotomies. Journal of Orthopaedic Research, 34(12), 2207–2214.

3. Fixatie van metatarsale osteotomieën met Mg-schroeven

Plaass, C., von Falck, C., Ettinger, S., Sonnow, L., Calderone, F., Weizbauer, A., Reifenrath, J., Claassen, L., Waizy, H., Daniilidis, K., Stukenborg-Colsman, C., & Windhagen, H. Bioabsorbable magnesium versus standard titanium compression screws for fixation of distal metatarsal osteotomies — 3 year results of a randomized clinical trial. Journal of Orthopaedic Science, 23(2), 321–327.

4. Biodegradeerbare Mg-schroeven bij osteonecrose heupkop

Zhao, D., Huang, S., Lu, F., Wang, B., Yang, L., Qin, L., Yang, K., Li, Y., Li, W., Wang, W., Tian, S., Zhang, X., Gao, W., Wang, Z., Zhang, Y., Xie, X., Wang, J., & Li, J. (2016). Vascularized bone grafting fixed by biodegradable magnesium screw for treating osteonecrosis of the femoral head. Biomaterials, 81, 84–92.

5. Mg-schroeven bij dijbeenhalsbreuken bij jongvolwassenen

Yu, X., Zhao, D., Huang, S., Wang, B., Zhang, X., Wang, W., & Wei, X. (2015). Biodegradable magnesium screws and vascularized iliac grafting for displaced femoral neck fracture in young adults. BMC Musculoskeletal Disorders, 16, 329.

6. Mg-ionen in titaniumimplantaten en botreactie

Hieu, P. D., Baek, D. H., Park, D. S., Park, J.-T., & Hong, K. S. (2013). Evaluation of stability changes in magnesium-incorporated titanium implants in the early healing period. The Journal of Craniofacial Surgery, 24(5), 1552–7.

7. Magnesiumverrijkte hydroxyapatiet en botgenezing

Windhagen, H., Radtke, K., Weizbauer, A., Diekmann, J., Noll, Y., Kreimeyer, U., Schavan, R., Stukenborg-Colsman, C., & Waizy, H. (2013). Biodegradable magnesium-based screw clinically equivalent to titanium screw in hallux valgus surgery: Short term results of the first prospective, randomized, controlled clinical pilot study. Biomedical Engineering Online, 12, 62.

8. Biodegradeerbare Mg-schroeven vs. titanium (hallux valgus)

Canullo, L., Heinemann, F., Gedrange, T., Biffar, R., & Kunert-Keil, C. (2013). Histological evaluation at different times after augmentation of extraction sites grafted with a magnesium-enriched hydroxyapatite: Double-blinded randomized controlled trial. Clinical Oral Implants Research, 24(4) 398–406.

9. Magnesiumcoronairstents – multicentrische studie

Erbel, R., Di Mario, C., Bartunek, J., Bonnier, J., de Bruyne, B., Eberli, F. R., Erne, P., Haude, M., Heublein, B., Horrigan, M., Ilsley, C., Böse, D., Koolen, J., Lüscher, T. F., Weissman, N., & Waksman, R. (2007). Temporary scaffolding of coronary arteries with bioabsorbable magnesium stents: A prospective, non-randomised multicentre trial. Lancet, 369(9576), 1869–1875.

Systematische Reviews & Meta-Analyses van Moleculaire Waterstof

Antioxidantcapaciteit bij inspanning

1. Kan moleculaire waterstof oxidatieve stress door inspanning verminderen bij gezonde volwassenen?

Li Y, Bing R, Liu M, Shang Z, Huang Y, Zhou K, Bao D, Zhou J. Can molecular hydrogen supplementation reduce exercise-induced oxidative stress in healthy adults? A systematic review and meta-analysis. Front Nutr. 2024 Mar 25;11:1328705. doi: 10.3389/fnut.2024.1328705. PMID: 38590828; PMCID: PMC10999621.

Invloed op cholesterolwaarden:

2. Effect van waterstofrijk water op bloedlipiden in klinische populaties

Todorovic N, Fernández-Landa J, Santibañez A, Kura B, Stajer V, Korovljev D, Ostojic SM. The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Clinical Populations: A Systematic Review and Meta-Analysis. Pharmaceuticals. 2023; 16(2):142. https://doi.org/10.3390/ph16020142

Vermoeidheid & uithoudingsvermogen:

3. Waterstofsuppletie en de impact op vermoeidheid en aerobe capaciteit bij gezonde volwassenen

Zhou K, Liu M, Wang Y, Liu H, Manor B, Bao D, Zhang L and Zhou J (2023) Effects of molecular hydrogen supplementation on fatigue and aerobic capacity in healthy adults: A systematic review and meta-analysis. Front. Nutr. 10:1094767. doi: 10.3389/fnut.2023.1094767

Toepassing bij kankerbehandeling

4. Systematisch overzicht van moleculaire waterstof bij kankerzorg

Mohd Noor MNZ, Alauddin AS, Wong YH, Looi CY, Wong EH, Madhavan P, Yeong CH. A Systematic Review of Molecular Hydrogen Therapy in Cancer Management. Asian Pac J Cancer Prev. 2023 Jan 1;24(1):37-47. doi: 10.31557/APJCP.2023.24.1.37. PMID: 36708550; PMCID: PMC10152878.

5. Anti-inflammatoire en antioxidanten effecten van hoge H₂-concentraties bij longziekten

Xiao K, Liu J, Sun Y, Chen S, Ma J, Cao M, Yang Y, Pan Z, Li P and Du Z (2024) Anti-inflammatory and antioxidant activity of high concentrations of hydrogen in the lung diseases: a systematic review and meta-analysis. Front. Immunol. 15:1444958. doi: 10.3389/fimmu.2024.1444958

6. Effect van waterstofwater op cholesterol bij mensen met metabole stoornissen

Jamialahmadi H, Khalili-Tanha G, Rezaei-Tavirani M, Nazari E. The Effects of Hydrogen-Rich Water on Blood Lipid Profiles in Metabolic Disorders Clinical Trials: A Systematic Review and Meta-analysis. Int J Endocrinol Metab. 2024;22(3):e148600. https://doi.org/10.5812/ijem-148600.

7. Invloed van moleculaire waterstof op de leverfunctie: overzicht & meta-analyse

Todorovic, N., Ostojic, S.M. (2024). Dihydrogen and Hepatic Function: Systematic Review and Meta-analysis. In: Slezak, J., Kura, B. (eds) Molecular Hydrogen in Health and Disease. Advances in Biochemistry in Health and Disease, vol 27. Springer, Cham. https://doi.org/10.1007/978-3-031-47375-3_16